:root{font-family:Inter,"Segoe UI","Microsoft YaHei",system-ui,sans-serif;color:#16363c;background:#eef2f2;font-synthesis:none;--ink:#12373d;--muted:#64787d;--green:#166d61;--line:#dce5e5;--red:#c34643;--gold:#996620}*{box-sizing:border-box}body{margin:0}button,input,select{font:inherit}button,a,input,select{ -webkit-tap-highlight-color:transparent}button,a,select{touch-action:manipulation}button{cursor:pointer}a{color:var(--green);text-underline-offset:3px}button:disabled{cursor:not-allowed;opacity:.43}button:focus-visible,a:focus-visible,input:focus-visible,select:focus-visible,[role=button]:focus-visible{outline:3px solid #48a99d;outline-offset:3px}.boot{padding:80px;text-align:center}header{position:sticky;top:0;z-index:20;background:#102e34;color:white;padding:0 28px;min-height:80px;display:flex;align-items:center;gap:32px}.brand{display:flex;align-items:center;gap:12px;white-space:nowrap}.brand img{width:40px;height:40px}.brand b{font-size:19px;letter-spacing:-.6px}.brand small{display:block;color:#9ab8bc;font-size:12px;letter-spacing:1.7px;margin-top:4px}nav{display:flex;align-self:stretch;gap:4px}nav button{border:0;border-bottom:3px solid transparent;color:#b6cbce;background:transparent;padding:0 17px;font-size:14px;font-weight:600}nav button.active{color:#fff;border-color:#95e4c9}.lang{margin-left:auto;display:flex;gap:2px;background:#224047;border-radius:7px;padding:4px}.lang button{font-size:13px;background:none;color:#c3d6d8;border:0;padding:8px 10px;border-radius:4px}.lang button.active{background:#e4f2ef;color:#153e3d;font-weight:700}.topline{padding:18px 28px;background:white;border-bottom:1px solid var(--line);display:flex;gap:24px;align-items:center}.searchbox{position:relative;flex:1;max-width:650px}.searchbox svg{position:absolute;left:13px;top:13px;width:19px;height:19px;color:#597176}.searchbox input{width:100%;border:1px solid #cddcdd;border-radius:8px;padding:12px 42px;font-size:15px;background:#f8fafa}.searchbox button{position:absolute;right:6px;top:5px;border:0;background:transparent;font-size:23px;color:#6a7d7e}.counts{margin-left:auto;display:flex;gap:25px;color:var(--muted);font-size:12px}.counts strong{font-size:20px;display:block;color:#24434a;font-variant-numeric:tabular-nums}.workspace{display:grid;grid-template-columns:246px minmax(0,1fr);min-height:calc(100vh - 164px)}.sidebar{background:#f7f9f9;border-right:1px solid var(--line);padding:23px 14px;max-height:calc(100vh - 163px);position:sticky;top:163px;overflow:auto}.sidebar-head{display:flex;justify-content:space-between;padding:0 10px;align-items:center;margin-bottom:16px}.sidebar-head h2{font-size:14px;margin:0}.sidebar-head span{font-size:12px;color:var(--muted)}.chips{display:flex;flex-wrap:wrap;gap:5px;margin:0 8px 17px}.chips button{font-size:12px;border:1px solid #d9e4e3;border-radius:5px;background:white;padding:5px 8px;color:#4b666c}.chips 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12px;background:#e4eee9;border:1px solid #cfdfd7;color:#32624d;border-radius:6px;white-space:nowrap;font-size:14px}.lab-grid{display:grid;grid-template-columns:minmax(0,1fr) 292px;gap:18px;align-items:start}.stage-card{background:white;border:1px solid #d8e3e3;border-radius:12px;overflow:hidden;box-shadow:0 4px 24px #15373b04}.stage-toolbar{display:flex;align-items:center;justify-content:space-between;padding:15px 18px;border-bottom:1px solid #e6eceb;gap:12px}.mode-switch{display:flex;border:1px solid #dbe5e3;border-radius:6px;padding:3px;background:#f5f8f7}.mode-switch button{border:0;background:transparent;border-radius:4px;padding:8px 19px;font-size:14px;color:#67807d}.mode-switch button.active{background:#163d3d;color:white;box-shadow:0 2px 4px #102e3410}.site-select{display:flex;align-items:center;gap:7px;font-size:13px;color:#687e80}.site-select select{padding:6px 9px;max-width:200px;border:1px solid #d1dfdd;border-radius:5px;background:#fff;color:#264447;font-size:14px}.legend{display:flex;flex-wrap:wrap;gap:14px;font-size:12px;color:#536c70;padding:14px 22px 0}.dot{width:10px;height:10px;display:inline-block;margin-right:6px;border-radius:3px}.diagram-wrap{position:relative;min-height:340px;background-image:radial-gradient(#dce7e7 .65px,transparent .65px);background-size:20px 20px}.diagram-wrap svg{width:100%;height:auto;display:block;min-height:340px}.diagram-label{font-family:inherit;fill:#536e74;font-size:19px}.node-text{font-size:20px;fill:#16363c;text-anchor:middle;dominant-baseline:middle;font-weight:500}.sugar-text{fill:#fff;font-size:20px;font-weight:600}.bond-target{cursor:pointer}.bond-target .bond-hot{stroke:#cf5149;stroke-width:4;stroke-linecap:round}.bond-target:hover .bond-hot{stroke-width:7}.bond-target.selected .bond-hot{stroke:#d44d48;stroke-width:5}.bond-tag{fill:#c14b44}.bond-hit{stroke:transparent;stroke-width:32;fill:none}.graph-note{margin:0 20px 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h2{font-size:13px;text-transform:uppercase;letter-spacing:.5px;color:#4e7367;margin:0 0 10px}.info-block p{font-size:14px;line-height:1.8;margin:0;color:#506c6a}.footer{display:flex;gap:20px;justify-content:space-between;align-items:center;font-size:12px;color:#839391;padding:22px 2px 2px;line-height:1.7}.footer a{white-space:nowrap}.page{max-width:1500px;margin:auto;padding:32px 28px}.page h1{font-size:30px;margin:0 0 10px;letter-spacing:-.8px}.page-intro{font-size:15px;color:#6b817f;line-height:1.7;margin:0 0 24px}.filters{display:flex;gap:10px;flex-wrap:wrap;margin:20px 0}.filters select,.filters button{font-size:14px;border:1px solid #cbdad6;border-radius:6px;padding:9px 12px;background:white;color:#42655c}.result-count{font-size:13px;color:#6d817a;margin-bottom:14px}.enzyme-cards{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:16px}.enzyme-card{background:white;border:1px solid #d4e2db;border-radius:10px;padding:21px;display:flex;flex-direction:column;min-width:0}.enzyme-card .card-top{display:flex;justify-content:space-between;gap:8px;align-items:start}.enzyme-card h2{font-size:22px;margin:0;letter-spacing:-.5px;overflow-wrap:anywhere}.enzyme-card .taxon{font-size:13px;color:#718779;font-style:italic;margin:7px 0 14px}.enzyme-card p{font-size:14px;line-height:1.7;color:#547267}.site-badges{display:flex;gap:6px;flex-wrap:wrap}.site-badges span{font-family:ui-monospace,monospace;font-size:12px;background:#f0f4f1;border-radius:4px;padding:5px 8px;color:#557c6b}.card-more{font-size:13px;color:#44705e;line-height:1.7;margin:13px 0 18px}.card-more summary{cursor:pointer}.card-more p{font-size:13px}.card-bottom{margin-top:auto;display:flex;justify-content:space-between;gap:8px;align-items:center}.small-button{font-size:13px;border:1px solid #cbded1;background:#eef5f0;padding:7px 10px;color:#36634d;border-radius:5px}.table-wrap{overflow:auto;border:1px solid #d4e2da;border-radius:10px;background:white}table{border-collapse:collapse;width:100%;font-size:14px}th{background:#e9f1ec;color:#456858;text-align:left;font-weight:600;padding:17px 20px;white-space:nowrap}td{padding:16px 20px;border-top:1px solid #e5eee7;line-height:1.65;color:#526d5e}td:first-child{color:#224838;font-weight:500}td .small-button{white-space:nowrap}.reference-list{display:grid;gap:10px}.reference-item{background:white;border:1px solid #d7e3dd;border-radius:8px;padding:20px;display:grid;grid-template-columns:60px 1fr;gap:12px}.reference-item span{font-size:13px;font-family:ui-monospace,monospace;color:#47745b}.reference-item a{font-size:15px;line-height:1.6;text-decoration:none;overflow-wrap:anywhere}.empty{padding:55px 24px;text-align:center;color:#72847e;font-size:16px}.mobile-select{display:none}.status-message{font-size:13px;line-height:1.7;padding:13px 16px;background:#fff4df;color:#876527;border-radius:6px;margin:15px 0}.a11y-status{position:absolute;width:1px;height:1px;overflow:hidden;clip-path:inset(50%)}
@media(min-width:1800px){.workspace{grid-template-columns:270px 1fr}.lab-grid{grid-template-columns:minmax(0,1fr) 350px}.panel{padding:24px}.diagram-wrap svg{max-height:690px}.workbody{padding:32px}}
@media(max-width:1250px){header{gap:16px;padding:0 20px}nav button{padding:0 11px}.brand b{font-size:17px}.workspace{grid-template-columns:222px minmax(0,1fr)}.workbody{padding:22px 20px}.lab-grid{grid-template-columns:minmax(0,1fr)}.panel{display:grid;grid-template-columns:220px 1fr;column-gap:24px}.panel .selection{grid-row:1/8}.panel h2{grid-column:1/-1}.enzyme-title{margin-top:0}.info-grid{grid-template-columns:1fr 1fr}.counts{gap:15px}.counts strong{font-size:18px}.enzyme-cards{grid-template-columns:repeat(2,minmax(0,1fr))}}
@media(max-width:850px){header{padding:14px 18px;flex-wrap:wrap;gap:14px;min-height:0;position:relative}.brand b{font-size:18px}nav{order:3;width:100%;gap:0;justify-content:space-between}nav button{padding:12px 6px;font-size:13px}.lang{margin-left:auto}.lang button{padding:7px}.topline{padding:14px 18px}.counts{display:none}.workspace{display:block}.sidebar{display:none}.mobile-select{display:block;width:100%;padding:11px;background:white;border:1px solid #ceded6;border-radius:6px;margin-bottom:20px;color:#33594a;font-size:14px}.workbody{padding:20px 16px}.plate-head h1{font-size:24px}.plate-head{gap:12px}.cross-pill{padding:7px;font-size:12px}.diagram-wrap svg{min-height:260px}.diagram-wrap{min-height:260px}.stage-toolbar{padding:12px;flex-wrap:wrap}.stage-toolbar .site-select{margin-left:auto}.mode-switch button{padding:7px 13px}.info-grid{grid-template-columns:1fr}.footer{align-items:flex-start;flex-direction:column;gap:10px}.page{padding:24px 18px}.page h1{font-size:26px}.enzyme-cards{grid-template-columns:1fr 1fr}.transport{flex-wrap:wrap}.transport input{flex:1}.stages span{font-size:11px}.stages{gap:6px}.timeline{padding:15px 13px}.legend{padding:13px 14px 0;gap:10px}.graph-note{margin:0 14px 15px}.reference-item{grid-template-columns:42px 1fr;padding:17px}}
@media(max-width:560px){.brand small{display:none}.brand img{width:31px;height:31px}.brand b{font-size:16px}.lang{gap:0;padding:3px}.lang button{font-size:12px;padding:6px}.panel{display:block}.panel .selection{margin-bottom:20px}.enzyme-cards{grid-template-columns:1fr}.enzyme-title{font-size:23px}.stage-toolbar .site-select{margin-left:0;max-width:100%}.site-select select{max-width:170px}.plate-head h1{font-size:22px}.plate-head{align-items:flex-start}.cross-pill{font-size:11px}.stages span{display:block;font-size:10px;line-height:1.5}.stages i{margin-bottom:5px}.transport input{flex-basis:130px}.transport button{padding:8px}.transport select{width:46px}.diagram-wrap{overflow:auto}.diagram-wrap svg{min-width:670px;min-height:380px}.counts{display:none}.page-intro{font-size:14px}.graph-note{font-size:12px}.footer{font-size:12px}}
@media(prefers-reduced-motion:reduce){*{scroll-behavior:auto!important}}

.lab-grid>div,.stage-card,.info-block{min-width:0}.stages i{width:19px;flex-shrink:0}.diagram-wrap{max-width:100%}

.role-tags{display:flex;gap:5px;flex-wrap:wrap;margin:12px 0}.role-tags span{font-size:11px;border:1px solid #d6e4df;color:#456e62;background:#eff6f2;border-radius:5px;padding:5px 7px}.enzyme-card .aliases{font-size:12px;color:#7b877e;overflow-wrap:anywhere;margin:0 0 12px}.catalog-explainer{background:#e4eeea;border-left:3px solid #548674;color:#46695d;padding:13px 17px;font-size:14px;line-height:1.7;border-radius:4px}.catalog-jump{margin-top:15px}.audit-section{margin:30px 0}.audit-section h2{font-size:21px}.audit-grid{display:grid;grid-template-columns:repeat(5,minmax(0,1fr));gap:12px}.audit-card{background:white;border:1px solid #dae5df;border-radius:8px;padding:18px}.audit-card strong{font-size:23px;color:#35725b}.audit-card h3{font-size:15px;margin:10px 0}.audit-card p{font-size:13px;line-height:1.6;color:#708275}.filters select{max-width:100%}.mode-switch button{padding:8px 11px}.filters{align-items:center}.filters select{max-width:280px}@media(max-width:1200px){.audit-grid{grid-template-columns:repeat(3,minmax(0,1fr))}}@media(max-width:650px){.audit-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.mode-switch button{font-size:12px;padding:7px}.filters select{width:100%;max-width:100%}.catalog-explainer{font-size:13px}}

.share-controls{display:flex;gap:12px;align-items:center;justify-content:flex-end;flex-wrap:wrap;padding:10px 28px;background:#f8faf9;border-bottom:1px solid var(--line);font-size:12px;color:#42665d}.share-controls input{width:100%;padding:8px;border:1px solid #ccdcd5;border-radius:5px}.pagination{display:flex;align-items:center;justify-content:center;flex-wrap:wrap;gap:14px;margin:20px 0;font-size:13px;color:#42665d}.pagination button{padding:10px 14px;border:1px solid #cbded1;border-radius:6px;background:white;color:#36634d}.entry-actions{display:flex;gap:6px;flex-wrap:wrap;justify-content:flex-end}.card-bottom{flex-wrap:wrap}.mobile-enzyme{display:none}.filters{scroll-margin-top:100px}input[type=search]::-webkit-search-cancel-button{-webkit-appearance:none}.footer a{white-space:normal}.panel .role-tags{min-width:0}
@media(max-width:850px){.mobile-enzyme{display:flex;flex-direction:column;gap:8px;font-size:13px;color:#4b6862;margin-bottom:18px}.mobile-enzyme select{width:100%;padding:12px;border:1px solid #ccdcda;background:#fff;border-radius:6px;color:#234744}.share-controls{padding:10px 18px;justify-content:flex-start}.filters{scroll-margin-top:15px}}